Small Animal Imaging Core

Director: John Sunderland, PhD
Associate Professor, Radiology
319-356-4104
Visit the core's homepage.

Purpose

To provide a comprehensive service for non-invasive anatomical and physiological imaging of mice and rats. The ultimate product of the core involves spatial imaging (high resolution pictures) and temporal imaging (longitudinal studies) related to cancer biology, drug development, and assessment of therapeutic intervention.

Services Provided

  1. Consultation on development of imaging protocol(s)
  2. Assistance with ACURF submission(s)
  3. Animal preparation and monitoring prior to and during imaging
  4. Single or multiple modality imaging, and
  5. Image reconstruction, data reduction/analysis and result interpretation.

The core instrumentation consists of several imaging modalities which have been specifically purchased or modified for scanning small rodents include:

  • PET
  • SPECT
  • gamma camera
  • autoradiography
  • CT
  • MRI
  • US
  • optical imaging

Hours of Operation

Varied hours of operation - all units are available during the normal working hours of 8 a.m.  to 5 p.m. with direct assistance from core staff. The resources of the core are also available to all appropriately trained HCCC investigators for use outside the normal working hours. Special arrangements need to be made for PET, SPECT and gamma camera studies to ensure radiophamraceutical avaialbility for requested imaging times.

The core staff will assist investigators with defining which one or more of the imaging modalities are appropriate for their project. The core will work with the investigators to develop a time table for experiments, determine suitable numbers of animals to demonstrate feasibility and/or significance and assist the entire research team with imaging sequences. The core will utilize awake imaging whenever possible to limit animal complications and mortality. The staff will also assist with collaborations between HCCC investigators and other experts across the entire UI campus in order to facilitate synthesis of new radiopharmaceuticals, contrast agents, specialized techniques, etc that may be necessary for specific experiments.