University of Iowa Hospitals and Clinics
Participants in this study are undergoing tumor resections with endoprosthetic replacements. Limb salvage surgery is the standard of care in the management of sarcoma of the long-bones. Advances in chemotherapeutic regimens and imaging techniques allow for wide resection and functional reconstruction in the 95% of patients. The most common type of long-bone reconstruction involves the use of a tumor prosthesis, or endoprostheses. Due to the complexity and length of surgical resection and reconstruction, as well as the immunocompromised nature of patients treated with chemotherapy, the risk for infection remains high. The purpose of this study is to investigate whether a long term (5 days) postoperative antibiotic regimen will decrease the rate of infection among patients being surgically treated for a lower extremity bone tumor when compared to a short term (24 hours) postoperative antibiotic regimen. About 1000 participants will take part in this study at centers around the country; approximately 20 participants will take part in this study at the University of Iowa.
Nancy McCurdy 319-356-8699
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