The purpose of this study is to determine whether the mechanisms (biological reasons) of how a single meal high in saturated fat or trans- fat causes a temporary impairment of blood vessel function in younger and older adults and how regular physical activity (exercise) may prevent this from occurring. If this does occur, we may better understand the mechanisms of vascular dysfunction and how to prevent this in patients in the future.
We are inviting you to participate in this research study because you are a non-smoking healthy male or female not on medications for high cholesterol and are between age of 18 -35 or 50-79 years and are sedentary, often not physically active (50-79 group) or highly physically active (50-79 group only). Women over 50 years of age will be postmenopausal for at least the past 1 year.
If you agree to take part in this study, your involvement will last for approximately 4-5 weeks and involve 5 separate visits. Visits will range from 1 to 5 hours. Visit 1 will last approximately 1 hour and Visit 2 will last approximately 2 hours. These are your screening visits and will determine your eligibility to participate in the study. If you are eligible to continue, Visits 3, 4 and 5 will occur over a 3 week period and each will last approximately 5 hours.