UI Hospitals and Clinics

Clinical Trial Details

Short Title
Official Title

Saturated and TRans Fat Meal-Induced Vascular Dysfunction with Aging and Exercise in Humans (STRIVE)




The purpose of this study is to determine whether the mechanisms (biological reasons) of how a single meal high in saturated fat or trans- fat causes a temporary impairment of blood vessel function in younger and older adults and how regular physical activity (exercise) may prevent this from occurring. If this does occur, we may better understand the mechanisms of vascular dysfunction and how to prevent this in patients in the future.

We are inviting you to participate in this research study because you are a non-smoking healthy male or female not on medications for high cholesterol and are between age of 18 -35 or 50-79 years and are sedentary, often not physically active (50-79 group) or highly physically active (50-79 group only). Women over 50 years of age will be postmenopausal for at least the past 1 year.

If you agree to take part in this study, your involvement will last for approximately 4-5 weeks and involve 5 separate visits. Visits will range from 1 to 5 hours. Visit 1 will last approximately 1 hour and Visit 2 will last approximately 2 hours. These are your screening visits and will determine your eligibility to participate in the study.  If you are eligible to continue, Visits 3, 4 and 5 will occur over a 3 week period and each will last approximately 5 hours.


Start Date
October 1, 2013
End Date
April 24, 2014
Gender Preference
Age Group
18 - 79 years
Principal Investigator
Gary L. Pierce, PhD
Contact Info

Kaitlyn Dubishar    Phone: (319) 353-3037

Department of Health and Human Physiology

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