University of Iowa Hospitals and Clinics
The purpose of this study is to test the safety of dabrafenib, which targets the BRAF gene and trametinib, which aims at a different cell signalling gene called MEK. Investigators also would like to see how well they work together compared to another drug vemurafenib, also known as Zelboraf®, which also targets the BRAF gene. Participants in this study will receive both dabrafenib and trametinib in combination together or receive vemurafenib alone. Dabrafenib and trametinib are not approved for doctors to prescribe to patients. Vemurafenib (Zelboraf®) is approved for certain types of advanced melanoma and is available in some countries but not everywhere. About 1000 patients have received dabrafenib, about 1220 have received trametinib and about 360 have received the combination of dabrafenib and trametinib in other studies, so far. About 700 people in 30 countries will take part in this study. The type of melanoma a participant must have in order to take part in this study occurs in about half of the people that have melanoma.
Melanie Frees, 319-356-1228
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