Participants in this research study have been diagnosed with angiosarcoma that is unable to be removed by surgery. The purpose of this research study is to find out what effects, good and/or bad, an experimental drug called AMG 386 has on the angiosarcoma. Approximately 5 people will take part in this study conducted by investigators at the University of Iowa. About 41 subjects will take part in this study nationwide. Study treatment will last as long as it is helping the cancer.