University of Iowa Hospitals and Clinics

Clinical Trial Details

Short Title
Official Title
A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma

Participants are being asked to take part in this research study because they have been diagnosed with a type of tumor called Ewing sarcoma that is localized. Ewing sarcoma is a type of tumor that occurs in the bones or the soft tissues around the bones. A localized tumor is one that has not spread to any other places in the body.

It is common to enroll children and adolescents with cancer in a clinical trial that seeks to improve cancer treatment over time. Clinical trials include only people who choose to take part. Study participants have a choice between a standard treatment for Ewing sarcoma and this clinical trial.

Six hundred and thirty (630) people are expected to enroll on this study. Approximately nine people will take part in this study conducted by investigators at the University of Iowa.

Start Date
November 16, 2012
End Date
November 16, 2022
Gender Preference
Age Group
0 - 99 years
Principal Investigator
Ayman El-Sheikh, MD
Contact Info

Julie de la Garza, 319-356-3749

AEWS1031 ; cancer ; el-sheikh ; ewing sarcoma ; IRB#201210720 ; pediatric ; phase 3 ; phase III ;

We welcome your feedback! Please help us improve your experience on our website by completing a brief survey.