University of Iowa Hospitals and Clinics

Clinical Trial Details

Short Title
ABS-LT
Official Title

Safety Study of Ambrisentan in Subjects With Pulmonary Hypertension

Description

ABS-LT: A Phase 3, Long-Term, Open Label, Multicenter Safety Study of Ambrisentan in Subjects With Pulmonary Hypertension

This Phase 3, international, multicenter, open-label study will monitor the long-term safety of ambrisentan in subjects with PH. The available ambrisentan doses for this study are 2.5, 5, or 10 mg once daily (qd); the approved doses in the United States, Canada, and the European Union are 5 and 10 mg ambrisentan qd. Investigators will be able to adjust ambrisentan dose as clinically indicated. Ambrisentan can be increased or decreased in one-step intervals, with a minimum of 4 weeks between dose adjustments. Subjects receiving other therapies for PH that are not contraindicated for concomitant use with ambrisentan are permitted to enroll in this study and continue to receive such therapies.

 

This study is closed to enrollment and in the follow-up phase.

 

Please refer to www.clinicaltrials.gov identifier: NCT00777920 for more information.

Start Date
June 1, 2008
End Date
January 31, 2015
Gender Preference
None
Age Group
18 - 99 years
Principal Investigator
Sif Hansdottir, MD
Contact Info

Pulmonary Hypertension Program

Page Scovel, RN

Phone:  319-356-1028

Fax;  319-356-7087

email:  page-scovel@uiowa.edu

Department
Department or Field of Study
Keywords
Heart ; High blood pressure in lungs ; PAH ; PH ; pulmonary arterial hypertension ; Pulmonary diseases ; Pulmonary hypertension ;

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