University of Iowa Hospitals and Clinics

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Physical Activity and Pain Perception

Principal Investigator
Laura Frey-Law
Department
Physical Rehabilitation Science

We are studying the association between fitness levels and the perception of musculoskeletal pain. 

We are inviting healthy, sedentary (don’t regularly exercise or exercise less than 100 minutes a week) and physically active (exercising 4+/wk or more than 150 minutes of moderate-vigorous activity per wk) adults between the ages of 18 and 45 to participate in a study involving temporary cold- and pressure-sensations on the arm and hand. 

The study involves temporary cold- and pressure-sensations on the arm and hand. Visits also includes questionnaires, wearing an activity monitor for 1 week, and a 3-minute submaximal fitness assessment. 

The study will consist of two visits approximately 1 week apart:

1st visit is approximately 30 minutes & 2nd visit is approximately 45 minutes.

Compensation provided.

age group:18 to 45 years trial start date:February 3, 2014
Gender Preference:none Trial End Date: August 10, 2014
Contact Info:

Jackie Loesche or Shannon Merkle @ 319-335-9795

or Jacquelyn-loesche@uiowa.edu or shannon-merkle@uiowa.edu

 

Keywords: exercise ; fitness ; healthy active adults ; healthy sedentary adults ; pain

Ketogenic Diet

Principal Investigator
Sudershan Bhatia, MD
Department
Department or Field of Study

Participants in this research study have been diagnosed with pancreatic cancer and recommended for chemotherapy and radiation therapy by their doctor. The purpose of the study is to determine the effects, good and bad, of subject's participation in a special ketogenic diet, with very low level of carbohydrates (sugars), during chemotherapy and radiation therapy for pancreatic cancer. Animal research suggests that lower blood sugars increase treatment effect. That is why we are doing research on this special diet.

age group:18 to 99 years trial start date:June 3, 2011
Gender Preference:none Trial End Date: June 3, 2021
Contact Info:

sandy-vollstedt@uiowa.edu

Keywords: bhatia ; cancer ; ketogenic diet ; pancreatic cancer ; phase 1 ; phase I

Ketogenic Diet

Principal Investigator
Sudershan Bhatia, MD
Department
Department or Field of Study

Participants in this study have been diagnosed with lung cancer and their doctor has recommended chemotherapy and radiation therapy. The purpose of this research study is to determine the effects, good and bad, that using a special diet has on participants during chemotherapy and radiation therapy for lung cancer.  Current research in animals suggests that lowering glucose helps increase treatment effects. That is why we are investigating this low-sugar diet.

age group:18 to 99 years trial start date:June 3, 2011
Gender Preference:none Trial End Date: June 3, 2021
Contact Info:

sandy-vollstedt@uiowa.edu

Keywords: bhatia ; cancer ; ketogenic diet ; lung cancer ; phase 1 ; phase I

Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY)

Principal Investigator
Benjamin Miller MD
Department
Orthopaedics

Participants in this study are undergoing tumor resections with endoprosthetic replacements. Limb salvage surgery is the standard of care in the management of sarcoma of the long-bones. Advances in chemotherapeutic regimens and imaging techniques allow for wide resection and functional reconstruction in the 95% of patients. The most common type of long-bone reconstruction involves the use of a tumor prosthesis, or endoprostheses. Due to the complexity and length of surgical resection and reconstruction, as well as the immunocompromised nature of patients treated with chemotherapy, the risk for infection remains high. The purpose of this study is to investigate whether a long term (5 days) postoperative antibiotic regimen will decrease the rate of infection among patients being surgically treated for a lower extremity bone tumor when compared to a short term (24 hours) postoperative antibiotic regimen. About 1000 participants will take part in this study at centers around the country; approximately 20 participants will take part in this study at the University of Iowa.

age group:0 to 99 years trial start date:May 6, 2014
Gender Preference:none Trial End Date: December 1, 2015
Contact Info:

Nancy McCurdy      319-356-8699

Keywords: Cancer ; Endoprosthetic ; Miller ; Tumor

Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab (TCHP) With or Without Estrogen Deprivation

Principal Investigator
Alexandra Thomas, MD
Department
Hematology/Oncology

Participants in this research study have breast cancer that is HER2-positive and is sensitive to hormones. The purpose of this research study is to compare the good and bad effects of using hormone drugs with the usual chemotherapy drugs to using the chemotherapy drugs alone as therapy given before surgery.

Approximately 7 people will take part in this treatment study conducted by investigators at the University of Iowa. There will be about 212 people taking part in this study nationally.

age group:18 to 99 years trial start date:May 2, 2014
Gender Preference:female Trial End Date: January 1, 2017
Contact Info:

Pamela Zehr      319-353-8914

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