Our Special Expertise in aHUS, C3GN and DDD

There are a number of kidney diseases that are a result of altered regulation of the immune system. These diseases not only can progress to end-stage kidney disease if untreated but can come back in the transplanted kidney and cause renal failure all over again.

The University of Iowa has special expertise in the evaluation and management of several of these diseases. Atypical hemolytic uremic syndrome (aHUS) is such a disorder for which new treatments have been identified and several patients from around the country have been successfully transplanted here. Another type of kidney disease called C3 glomerulopathy (C3GN) or membranoproliferative glomerulonephritis (MPGN), which also includes dense deposit disease (DDD), has a genetic and immunologic basis and can be difficult to treat when it returns in the transplanted kidney.

The Organ Transplant Center partners with the Rare Renal Disease and Renal Genetics Clinic, a multi-disciplinary clinic whose purpose is to serve the Iowa community as well as physicians throughout the United States and abroad in the evaluation and management of rare renal diseases in the adult and pediatric patient. This clinic has a national reputation in complement mediated (a critical part of the immune system) renal diseases, such as atypical hemolytic uremic syndrome and the C3 glomerulopathies, including dense deposit disease. The clinical team works with Richard Smith, MD and the Molecular Otolaryngology and Renal Research Laboratory at Iowa to provide genetic screening, specific testing, and molecular diagnosis.

Clinical experts at the University of Iowa sponsor an annual conference on atypical HUS and partner with the Foundation for Children with Atypical HUS to provide education and support for patients and their families.