Lindsey Malloy, DO, MPH
Medical School: Kansas City University of Medicine and Biosciences
Residency: Children’s Mercy Hospital & Clinics, University of Missouri at Kansas City
Research Interests: Biochemical changes caused by aortic aneurysm actin mutations. The aim of this study is to determine the biochemical effects of TAAD mutations on actin monomer and filament function. TAAD mutations may alter actin monomer dynamics and polymerization kinetics in a mutation specific manner. We will determine the effects of one group of actin mutations in vivo on the actin dependent cellular processes and on the inherent biochemical properties of the mutant actins including; ability to exchange bound nucleotide, and filament formation kinetics. Block 2 mutations consist of G158D, R183Q, and R210Q. This data will advance understanding of how TAAD mutations alter elementary actin functions.
Luis Ochoa, MD
Medical School: University of Iowa Roy J. and Lucille A. Carver College of Medicine
Residency: University of Colorado, Denver / The Children's Hospital - Aurora
Research Interests: Regulation of Epithelial Sodium Channel Gating in Hypertension. The epithelial sodium channel (ENaC) forms a pathway for sodium reabsorption in the kidney collecting duct. Defects in ENaC regulation cause most of the known inherited forms of hypertension (e.g. Liddle’s syndrome). The overall goal of this project is to understand mechanisms that regulate ENaC activity. Focusing on naturally occurring sequence variation (polymorphisms), we will probe the role of the large extracellular domain in ENaC gating. In addition, we will test the hypothesis that sequence variants contributes to blood pressure variation in the population. Mentor: Peter Snyder
Govinda Paudel, MD
Medical School: B.P. Koirala Institute of Health Sciences, Nepal
Residency: Lincoln Medical and Mental Health Center, Bronx, NY
Research Interests: Computaitonal Fluid Dynamics in Cardiovascular Diseases: Computational fluid dynamics (CFD) is the emerging area of research in biomedical area. The principles of CFD can be applied to better understand the physiology and fluid dynamics of complex congenital heart disease both before and after surgical repairs. CFD can obviate the need for performing studies on experimental models, is less costly and provides quicker results. After creating the geometric models from patient-specific images of the cardiovascular structures or using the closest hypothetical models, behavior of the fluid (blood) in that reconstructed model can be studied by means of special software utilizing various mathematical equations. I am interested in exploring the application of CFD principles in the cardiovascular diseases or conditions that have not been studied before.
M. Santiago Restrepo, MD
Medical School: Facultad de Medicina Universidad de Antioquia (University of Antioquia, Medical School)
Residency: Woodhull Medical and Mental Health Center, Brooklyn, New York
Research Interests: In-vivo delivery of a viral vector for gene therapy in cystic fibrosis. We have developed a successful catheterization technique under fluoroscopic guidance for in-vivo delivery of a viral vector to the pancreas without causing morbidity or mortality to newborn swine. We have also been able to obtain transduction of eGFP (self complimentary green fluorescent protein) in pancreatic cells using AAV9 (Adeno associated virus 9) as a vector. We are currently working specifically on the transduction of non-self complementary GFP in the same swine model. Our future goal is to deliver and transduce the CFTR gene into the pancreatic cells in order to cure the pancreatic manifestations of the disease. Research Mentors: Aliye Uc, MD and Abhay Divekar, MD.
Experimental plan for contrast volume evaluation study. The aim of this study is to find the appropriate dose of a novel liposomal contrast agent for cardiac CT. This agent can last for up to 3 hours into the blood pool allowing good quality images without repetitive injections of contrast therefore causing less risk of nephrotoxicity. Research mentor: Abhay Divekar, MD and Eric A. Hoffman, MD