Current Fellows

 Muff-Luet, M

Melissa Muff-Luet, MD
Medical School: University of Minnesota Medical School
Residency: University of Iowa
Research Interests: My research interest currently involves renal targeted gene therapy in mice. I am working on a viral vector using the Adeno-associated virus 9 vector (AAV2/9) to target specific gene expression to the kidneys specifically the podocytes. I have well characterized the expression of AAV2/9 using a minimal nephrin promoter to drive GFP expression. We have found that the GFP appears to localize specifically to the podocytes in mice following systemic tail vein injection. Our future aims are to utilize this vector to re-introduce podocyte specific genes into mouse models of steroid resistant nephrotic syndrome.

Lyndsay Harshman

Lyndsay Harshman, MD
Medical School: University of Iowa Carver College of Medicine
Residency: University of Iowa
Research Interests: My research interests involve the impact of chronic disease on cognition in pediatric chronic kidney disease (CKD). I am particularly interested in medical decision-making in CKD, particularly in adolescence and the transition to early adulthood. I am currently investigating the impact of chronic kidney disease on academic achievement using a linkage analysis between the Iowa Testing Programs and patient medical data from the University of Iowa Children's Hospital. Future goals include using behavioral tasks, neuroimaging (both structural and functional), and psychophysiological measurement to understand the impact of CKD on the developing brain.