Opportunities for Fellows

Research

 

Our division actively publishes in basic, translational and clinical research realms. All fellows in our program are required to complete two years of research. There are numerous opportunities for basic science lab research in any field of interest across all subspecialties including within our own division. Translational and basic sciences research within our division includes the work of Dr. Aliye Uc, involving mechanisms of pancreatic damage in cystic fibrosis using a porcine model, understanding etiology of acute recurrent and chronic pancreatitis in children (spearheading a multicenter study including 13 other pediatric gastroenterology centers in US and Canada) and the role of heme oxygenase in gut inflammation and oxidative stress. Dr. Warren Bishop and Dr. Riad Rahhal are active in clinical research in the field of constipation, enteral nutritional devices and placement techniques. Fellows also have the opportunity to find research mentors outside the division. Previous fellows have had mentors in Pediatric Critical Care, Neonatology, Immunology, Internal Medicine, Gastroenterology and Hematology Divisions.

Research poster presentation

The following is list of some of our division's recent publications:

  1. Uc, A, McDonagh AF, Stokes JB. Metabolism of heme in Caco-2 cells. Exp Physiol. 95:296-303, 2010.
  2. Alawi K, Mitros FA, Bishop WP, Rayhill S, Wu Y. A reduced segment II/III graft for neonatal liver failure with absence of detectable hepatocytes. A case report and literature review. Pediatr Transplant. 2010.
  3. Stumphy J, Al-Zubeidi D, Guerin L, Mitros F, Rahhal RM. Observations on use of montelukast in pediatric eosinophilic esophagitis: insights for the future. Dis Esophagus. 24(4):229-34, 2010.
  4. Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA IV, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, et al. Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth. Science Translational Medicine. 2010; 2:29ra31
  5. Al-Zubeidi D, Bishop WP, Rahhal RM. Identifying small bowel intussusception related to a gastroenteric feeding tube. Frontline Gastroenterol. 2:63-64, 2011
  6. Ebach DR, Vanderheyden AD, Ellison JM, Jensen CS. Lymphocytic esophagitis: a possible manifestation of pediatric upper gastrointestinal Crohn's disease. Inflamm Bowel Dis. 17(1):45-9, 2011
  7. Abu-El-Haija M, Stasheff S, Atkins DL, Bishop WP. Rheumatic fever in a patient receiving infliximab therapy for Crohn disease. 52(3):360-1, 2011
  8. Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov L, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Taft PJ, Rector MV, Hornick E, Nassar P, Samuel M, Richter SS, Uc A, et al. Low Levels of cftr Activity in CFTRDF508/DF508 Pigs Do Not Prevent the Gastrointestinal and Lung Disease of Cystic Fibrosis. Science Translational Medicine 3:74ra24, 2011
  9. Al-Zubeidi DRahhal RM. Safety techniques for percutaneous gastrostomy tube placement in Pierre Robin Sequence. JPEN J Parenter Enteral Nutr. 35(3):343-5, 2011
  10.  Abu-El-Haija M, Sinkora M, Meyerholz DK, Welsh MJ, McCray PB Jr, Butler J, Uc A. An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis. Pancreatology. 11(5):506-15, 2011
  11. Morinville VD, Husain SZ, Bai H, Barth B, Alhosh R, Durie PR, Freedman SD, Himes R, Lowe ME, Pohl J, Werlin S, Wilschanski M, Uc A; on Behalf of the INSPPIRE Group. Definitions of Pediatric Pancreatitis and Survey of Present Clinical Practices. J Pediatr Gastroenterol Nutr. 55(3):261-265, 2012
  12. Abu-El-Haija M, Ramachandran S, Meyerholz DK, Abu-El-Haija M, Griffin M, Giriyappa RL, Stoltz DA, Welsh MJ, McCray PB Jr, Uc A. Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways. Am J Pathol. 181(2):499-507, 2012
  13. Uc A, Zhu X, Wagner BA, Buettner GR, Berg DJ. Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers. J Pediatr Gastroenterol Nutr. 54(4):471-6, 2012
  14. Griffin M, Abu-El-Haija M, Abu-El-Haija M, Rokhlina T, Uc A. Simplified and versatile method for isolation of high-quality RNA from pancreas. Biotechniques. 52(5):332-4, 2012
  15. Al-Zubeidi D, Rahhal RM. Prospective Randomized Comparative Study of Low-Profile Balloon Gastrostomy Tubes in Children. Nutr Clin Pract. 2012 Dec;27(6):812-6
  16. Uc A, Giriyappa R, Meyerholz DK, et al. Pancreatic and biliary secretion are both altered in CF pigs. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;15303(8):G961-8
  17. Malloy L, Jensen M, Bishop W, Divekar A. "Downhill" esophageal varices in congenital heart disease. J Pediatr Gastroenterol Nutr. 2013 Feb;56(2)
  18. Benkov K, Lu Y, Patel A, Rahhal R, Russell G, Teitelbaum J; NASPGHAN Committee on Inflammatory Bowel Disease. Role of thiopurine metabolite testing and thiopurine methyltransferase determination in pediatric IBD. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):333-40
  19. Al-Zubeidi D, Demir H, Bishop WP, Rahhal RM. Gastrojejunal feeding tube use by gastroenterologists in a pediatric academic center. J Pediatr Gastroenterol Nutr. 2013 May;56(5):523-7
  20. Uc A. Predicting the severity of pediatric acute pancreatitis: are we there yet? J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):584-5
  21. Griffin MA, Restrepo MS, Abu-El-Haija M, Wallen T, Buchanan E, Rokhlina T, Chen YH, McCray PB Jr, Davidson BL, Divekar A, Uc A. A novel gene delivery method transduces porcine pancreatic duct epithelial cells. Gene Ther. 2013 Nov 21
  22. Lerner DG, Li BU, Mamula P, Fishman DS, Kramer R, Goh VL, El-Chammas K, Pentiuk SP, Rothbaum R, Gurrum B, Rahhal RM, Goday PS, Vitola B. Challenges in meeting fellowship procedural guidelines in pediatric therapeutic endoscopy and liver biopsy. J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):27-33
  23. Abu-El-Haija M, Schultz J, Rahhal RM. Effects of 70% ethanol locks on rates of central line infection, thrombosis, breakage, and replacement in pediatric intestinal failure. J Pediatr Gastroenterol Nutr. 2014 Jun;58(6):703-8.
  24.  Morinville VD, Lowe ME, Ahuja M, Barth B, Bellin MD, Davis H, Durie PR, Finley B, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Kumar S, Ooi CY, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A. Design and Implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014 Sep

 

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