Skin lesion of coccidioidomycosis
Skin lesions of coccidioidomycosis are a symptom of infection with the Coccidioides immitis fungus.
This article discusses skin lesions due to coccidioidomycosis. For more general information about this disease, see: Coccidioidomycosis
Causes, incidence, and risk factors
Coccidioidomycosis is a fungal infection most commonly seen in the desert regions of the southwestern United States, and in Central and South America. You get it by breathing in fungal particles (called spores) found in infected soil. The infection starts in the lungs.
After the lungs are infected, the fungus may spread to other tissues including the skin. The skin rash, or skin lesions, include erythema nodosum or erythema multiforme. They are thought to be caused by an immune response to the infection, rather than by the fungus itself.
Skin lesions are a sign of widespread (disseminated) fungal disease. Those who are at higher risk of developing widespread infection include:
- People of Native American, African, or Philippine descent
- Those with weakened immune systems due to AIDS, diabetes, or medications that suppress the immune system
- Skin lesion of the initial (primary) infection
- Erythema multiforme (target lesions)
- Erythema nodosum
- Papular rash
- Skin lesion of widespread (disseminated) disease: papule, pustule, nodule, or plaque
- May form abscesses
- May ulcerate
- Most often on the face
Signs and tests
The diagnosis depends on the stage of infection (primary or disseminated). If disseminated disease is suspected, the doctor may do a skin biopsy to look for the fungus in a skin lesion.
This infection is treated with antifungal medications. Oral or intravenous (directly into a vein) drugs will be used, depending on the form and stage of the disease. Antifungal agents used include amphotericin B, itraconazole, ketoconazole, or fluconazole. People with disseminated disease and a suppressed immune system may need long-term treatment.
What happens depends on the stage and extent of the infection, as well as the person's immune system. The highest mortality rate is seen in immunosuppressed people with disseminated disease.
- Additional skin infections caused by bacteria
- Complications related to medications (such as severe side effects)
- Skin abscess
Calling your health care provider
There are many types of skin lesions, and they can be hard to tell apart. Notify your medical provider if you develop skin lesions and suspect this condition, because you will need to be tested.
Galgiani JN. Coccidioidomycosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 354.
Last reviewed 9/15/2010 by David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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