Porphyrin urine test
The uroporphyrin test measures levels of porphyrins in urine. The most important function of porphyrins is as components of heme, which is made from iron plus protoporphyrin. Hemoglobin is made up of four globin proteins plus 4 heme groups. Oxygen binds to the iron in the heme molecules. Each step requires the presence of an enzyme. If any of the enzymes are deficient because of a genetic disease or inhibition by a toxic substance, a type of porphyria results.
Last reviewed 2/28/2011 by David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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