Stem cell research

Definition

A stem cell is a generic cell that can make exact copies of itself indefinitely. A stem cell has the ability to make specialized cells for various tissues in the body, such as heart muscle, brain tissue, and liver tissue. Stem cells can be saved and used later to make specialized cells, when needed.

There are two basic types of stem cells:

  • Embryonic stem cells - these are taken from aborted fetuses or fertilized eggs that are left over from in vitro fertilization (IVF). They are useful for medical and research purposes because they can produce cells for almost every tissue in the body.
  • Adult stem cells - these are not as versatile for research purposes because they are specific to certain cell types, such as blood, intestines, skin, and muscle. The term "adult stem cell" may be misleading because both children and adults have them.

Information

Potential uses for stem cells

There are many areas in medicine in which stem cell research could have a significant impact. For example, there are a variety of diseases and injuries in which a patient's cells or tissues are destroyed and must be replaced by tissue or organ transplants. Stem cells may be able to make brand new tissue in these cases, and even cure diseases for which there currently is no good therapy. Diseases that could be helped by stem cells include Alzheimer's and Parkinson's disease, diabetes, spinal cord injury, heart disease, stroke, arthritis, cancer, and burns.

Stem cells could also be used to gain a better understanding of how genetics work in the early stages of cell development. This can help scientists understand why some cells develop abnormally and lead to medical problems such as birth defects and cancer. This might help scientists learn how to prevent some of these diseases.

Finally, stem cells may be useful in the testing and development of drugs. Because stem cells can be used to create unlimited amounts of specialized tissue, such as heart tissue, it may be possible to test how drugs react on such tissues before testing the drugs on animals and humans. Drugs could be tested for effectiveness and side effects more rapidly.

Controversy about stem cell research

In August 2001, President George W. Bush approved limited federal funding for stem cell research. While stem cell research has the potential to provide major medical advances, including cures for many diseases, stem cell research is controversial.

The stem cell controversy is based on the belief by opponents that a fertilized egg is fundamentally a human being with rights and interests that need to be protected. Those who oppose stem cell research do not want fetuses and fertilized eggs used for research purposes. However, a team of scientists have developed a technique that was successful in generating mouse stem cells without destroying the mouse embryo. This technique has not yet been attempted on human embryonic tissue. Many other scientists are attempting to create more universally accepted forms of human embryonic stem cells, as well as other types of adult stem cells.

Supporters of stem cell research argue that the fertilized eggs are donated with consent from each couple and would be discarded anyway. Therefore, there is no potential for those fertilized eggs to become human beings. Fertilized eggs are not (at this time) being created specifically for stem cell research.

As with any moral and ethical issue, the controversy surrounding stem cell research will likely continue for quite some time.

The U.S. government released new stem cell guidelines in 2009. The new guidelines cover issues such as informed consent of donors and the wording of consent, as well as the issue of financial gain. The National Institutes of Health (NIH) maintains a register of stem cells, including human embryonic lines, that are eligible for government funding.

References

Okie S. Stem-cell research--signposts and roadblocks. N Engl J Med.2005 Jul 7;353(1):1-5.

Lindvall O, Kokaia Z. Stem cell therapy for human brain disorders. Kidney Int. 2005 Nov;68(5):1937-9.

Fukuda H, Takahashi J. Embryonic stem cells as a cell source for treating Parkinson's disease. Expert Opin Biol Ther. 2005 Oct;5(10):1273-80.

Green R. Can we develop ethically universal embryonic stem-cell lines? Nature Genet Rev. June 2007;8:480-485.

Lougheed T. New US guidelines for research on human embryos. CMAJ.2005 Jun 21;172(13):1672.

Zwillich T. Guidelines set ethical bar for US stem cell research. Lancet. 2005 May 7-13;365(9471):1612.

Revision

Last reviewed 11/2/2012 by Chad Haldeman-Englert, MD, FACMG, Wake Forest School of Medicine, Department of Pediatrics, Section on Medical Genetics, Winston-Salem, NC. Review provided by VeriMed Healthcare Network. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, and Stephanie Slon.

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